{"id":7733,"date":"2024-01-29T06:02:15","date_gmt":"2024-01-29T11:02:15","guid":{"rendered":"https:\/\/americacellbank.com\/sin-categorizar\/eli-and-sickle-cell-disease-a-story-of-biological-hope"},"modified":"2024-08-14T09:24:28","modified_gmt":"2024-08-14T14:24:28","slug":"eli-and-sickle-cell-disease-a-story-of-biological-hope","status":"publish","type":"post","link":"https:\/\/americacellbank.com\/en\/eli-and-sickle-cell-disease-a-story-of-biological-hope\/","title":{"rendered":"Eli and sickle cell disease, a story of biological hope"},"content":{"rendered":"\n

Eli is an African-American boy who was born again at the age of 11.\nThe vast majority of the 300,000 children<\/strong> born each year with sickle cell disease are not as lucky.\nBut Eli’s case, like those of Helen<\/a>, Diama<\/a>, Rev\u00e9e<\/a> and other patients before him, fills us with hope to fight one of the world’s most common genetic diseases<\/strong> with cellular treatment<\/strong>. <\/p>\n\n

In this article we will learn about Eli’s story and delve into sickle cell disease to understand why stem cells can bring hope back to so many families.<\/p>\n\n

Sickle cell disease, when hemoglobin changes your life<\/strong><\/h2>\n\n

Sickle cell disease (also called sickle cell anemia or sickle cell disease) is a group of inherited disorders<\/strong> in two mutant hemoglobin<\/strong> genes (one from each parent).<\/p>\n\n

When one parent has sickle cell disease and the other parent carries only one of the abnormal genes, such as hemoglobin S, their child has a 1 in 2 (50%) chance of having sickle cell disease.<\/strong><\/p>\n\n

When both parents carry a sickle cell gene, but are not sick, their child has a 1 in 4 (25%) chance of having sickle cell disease.<\/strong><\/p>\n\n

A person with sickle cell trait or carrier contains only one copy of the HbS gene and is generally considered healthy.\nIn this case the greatest risk lies in the transfer of the sickle hemoglobin gene to offspring.<\/strong> <\/p>\n\n

It is very likely that you are not a hematologist, so we remind you that hemoglobin<\/strong> is a protein rich in iron (which gives blood its characteristic red color), which transports oxygen from the lungs to the tissues and organs<\/strong> throughout the body.\nIn addition, it carries to the lungs all that<\/strong>CO2 that we do not need <\/strong>for anything and that these are responsible for expelling. <\/p>\n\n

A key job that keeps us alive every second, and which is usually performed to perfection by about 250 million hemoglobin molecules in each erythrocyte<\/strong> (red blood cell).\nIn fact, such a high concentration can influence the shape, deformability and viscosity of erythrocytes, <\/strong>characteristic of sickle cell disease. <\/strong> <\/p>\n\n

Since each hemoglobin molecule carries four oxygen molecules, an erythrocyte can carry about one billion oxygen molecules.\nAnd if we consider that each person has between 4,500,000 and 5,500,000 erythrocytes per cubic millimeter of blood, there may not be enough zeros to indicate the number of oxygen molecules carried in the 4.5-6 liters of blood flowing through our body.\nEven if we calculate only the oxygen-rich blood. <\/p>\n\n

In this context, the incidence of abnormal hemoglobin altered by genetic disorder is enormous:<\/strong><\/p>\n\n

\"Difference
Source: genotipia.com<\/a><\/figcaption><\/figure>\n\n